Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites
نویسندگان
چکیده
منابع مشابه
Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase
Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer. B13 is an effective and selective acid ceramidase inhibitor in vitro, but not as effective in cells due to poor access to the lysosomal compartment. In order to achieve targeting of B13 to the lysosome, we designed lyso...
متن کاملInterfacial Regulation of Acid Ceramidase Activity STIMULATION OF CERAMIDE DEGRADATION BY LYSOSOMAL LIPIDS AND SPHINGOLIPID ACTIVATOR
The lysosomal degradation of ceramide is catalyzed by acid ceramidase and requires sphingolipid activator proteins (SAP) as cofactors in vivo. The aim of this study was to investigate how ceramide is hydrolyzed by acid ceramidase at the water-membrane interface in the presence of sphingolipid activator proteins in a liposomal assay system. The degradation of membrane-bound ceramide was signific...
متن کاملhistological evaluation of the effect of three medicaments; trichloracetic acid, formocresol and mineral trioxide aggregate on pulpotomized teeth of dogs
چکیده ندارد.
15 صفحه اولInterfacial regulation of acid ceramidase activity. Stimulation of ceramide degradation by lysosomal lipids and sphingolipid activator proteins.
The lysosomal degradation of ceramide is catalyzed by acid ceramidase and requires sphingolipid activator proteins (SAP) as cofactors in vivo. The aim of this study was to investigate how ceramide is hydrolyzed by acid ceramidase at the water-membrane interface in the presence of sphingolipid activator proteins in a liposomal assay system. The degradation of membrane-bound ceramide was signific...
متن کاملEffect of Gibberllic acid and Salicylic acid on Secondary metabolites in leaf of Curcuma longa L.
Background & Aim: Turmeric, scientifically named (Curcuma longa L.), a member of ginger (Zingiberaceae) family, is a perennial plant, with pharmaceutical properties and with a rhizome. This plant has many medicinal characteristics including anti-cancer, anti-bacteria and anti-hepatitis properties. Experimental: To study the effects of Gibberellic acid and Salicylic acid on leaf, the r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2018
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2018.11.012